The role of the protein Rrm3 in the repair of breaks in DNA during replication
Date: June 8, 2017 Source: University of Seville Summary: Researchers have now gained a better understanding of the physiological mechanisms that prevent genetic instability. These findings have vital importance in the research against cancer, they say. FULL STORY A research group from the University of Seville has revealed the role that the protein Rrm3 plays in the repair of breaks that occur during the replication of DNA, by using the yeast Saccharomyces cerevisiae as a model organism. This protein belongs to the human protein family PIF1, the mutations of which are known to be associated with a higher risk of tumorigenesis. This opens the possibility that the risk of suffering cancer might be due to the inability of the cell to repair correctly breaks in DNA that happen during replication. The findings of this research, carried out by Sandra Muñoz Galván, María Luisa García Rubio, ...